--- src/busco/ConfigManager.py
+++ src/busco/ConfigManager.py
@@ -32,8 +32,9 @@
                 return
         except KeyError:
             pass
-        if os.environ.get("BUSCO_CONFIG_FILE") and os.access(os.environ.get("BUSCO_CONFIG_FILE"), os.R_OK):
-            self.config_file = os.environ.get("BUSCO_CONFIG_FILE")
+        config_file = os.environ.get("BUSCO_CONFIG_FILE") or "/opt/anaconda1anaconda2anaconda3/share/busco/config.ini"
+        if config_file and os.access(config_file, os.R_OK):
+            self.config_file = config_file
         else:
             raise SystemExit("Please specify a BUSCO config file using either "
                              "(i) an environment variable by entering 'export BUSCO_CONFIG_FILE=/path/to/config.ini' "