--- src/htslib-1.7/Makefile.Rhtslib	2018-10-30 20:47:25.000000000 +0100
+++ src/htslib-1.7/Makefile.Rhtslib	2018-10-30 20:47:25.000000000 +0100
@@ -43,7 +43,7 @@
 #CFLAGS   = -g -Wall -O2 -pedantic -std=c99 -D_XOPEN_SOURCE=600 -D__FUNCTION__=__func__
 CFLAGS   = -g -Wall -O2
 EXTRA_CFLAGS_PIC = -fpic
-LDFLAGS  =
+LDFLAGS  = "-L${PREFIX}/lib"
 LIBS     = $(htslib_default_libs)
 
 prefix      = /usr/local